Program
| 09.00 – 10.30 h / Room Tokio Opening Session Fifty Years of Interferons |
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| Bernhard Fleckenstein | Welcome Address | |
| Otto Haller | Fifty Years of Interferons | |
| Richard E. Randall | The interplay between viruses and the Interferon system | |
| Michael P. Manns | The treatment of Hepatitis C – the past, present and future role of Interferon | |
| Jean Lindenmann | European Virology Award (EVA) Lecture: Skeletons in the closets of interference research |
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10.30 - 11.00 h |
COFFEE BREAK |
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| 11.00 – 13.00 h / Room Tokio Workshop 1 Structure and Assembly |
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| Chair: | Franz X. Heinz, Rob Ruigrok | |
| Keynote Lecture: | Félix A. Rey: | |
| 11.00 - 11.30 h | Evolutionary and mechanistics insights from structural studies of viral fusion proteins | |
| 11.30 - 13.00 h | Oral presentations: | |
| The MCMV NEC interacts with the LBR complex at the inner nuclear membrane * Mark Lötzerich (1), Zsolt Ruzsics (1), Frederic Lemnitzer (1), Ulrich H. Koszinowski (1) (1) Max von Pettenkofer Institute, LMU, Munich, Germany |
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| Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles * Mouna Mhamdi (1), Anneke Funk (1), Heinz Hohenberg (1), Hans Will (1), Hüseyin Sirma (1) (1) Heinrich Pette Institut, Hamburg, Germany |
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| Characterization of a reactive groove in HIV-1 capsid protein defined by an in vitro assembly inhibitor * Vanda Bartonova (1), Jana Sticht (1), Peter Sehr (2), Joe Lewis (2), Sebastien Igonet (3), Felix Rey (3), Hans-Georg Kraeusslich (1) (1) University Heidelberg, Virology, Heidelberg, Germany; (2) EMBL, Chemical Biology Core Facility, Heidelberg, Germany; (3) Institute Pasteur, Structural Virology, Paris, France |
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| EBOV VP40 homooligomerization is essential for the formation of virus-like particles * T. Hoenen (1), F. Zielecki (2), U. Ströher (1), H. Feldmann (1), S. Becker (2) (1) Public Health Agency of Canada, NML, Winnipeg, Canada; (2) RKI, Berlin, Germany |
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| From structural proteomics of coronaviruses to antiviral drug discovery * Rolf Hilgenfeld University of Lübeck, Institute of Biochemistry, Lübeck, Germany |
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| Structure-function relationships in viral proteinases * Tim Skern (1), Carla Sousa (1), Christina Mayer (1), Eva Schmid (1), Luiza Deszcz (1), Ernst Kuechler (1), Regina Cencic (1), Nikolas Stefan (1) (1) Max F. Perutz Labs, Vienna, Austria |
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| 11.00 – 13.00 h / Room Istanbul Workshop 2 Plant Viruses |
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| Chair: | Rob W. Goldbach, Thomas Hohn | |
| Keynote Lecture: | Rob W. Goldbach: | |
| 11.00 - 11.30 h | Novel insights in virus-plant interactions | |
| 11.30 - 13.00 h | Oral presentations: | |
| The Silencing Suppressor P25 of Potato Virus X Interacts with Argonaute 1 Resulting in Degradation through Proteasome Pathway * Ching-Hsiu Tsai (1), David Baulcombe (2), Meng-Shuen Chiou (1) (1) National Chung Hsing University, Graduate Institute of Biotechnology, Taichung, TAIWAN; (2) John Innes Centre, The Sainsbury Laboratory, Norwich, United Kingdom |
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| Abutilon mosaic virus as a VIGS and protein expression vector * Björn Krenz (1), Christina Wege (1), Holger Jeske (1) (1) Universität Stuttgart, Biolog. Institut, Abt. Pflanzenvirologie, Stuttgart, Germany |
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| Characterisation of PKR: a Plant-Encoded, Double-Stranded RNA-Activated Protein Kinase *Elaine Chan (1), Michael Pearson (1), John Taylor (1), Dave Greenwood (2), Donald Roth (3), * Robin MacDiarmid (2) (1) University of Auckland, School of Biological Sciences, Auckland, New Zealand; (2) HortResearch, Plant-Pathogen Interactions, Auckland, New Zealand; (3) University of Wyoming, Molecular Biology, Laramie, USA |
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| Cross-protection with a CMV mutant lacking the 2b silencing suppressor gene * Heiko Ziebell (1), Tina Payne (2), James O. Berry (3), John Walsh (2), John Carr (1) (1) Cambridge University, Plant Sciences, Cambridge, United Kingdom; (2) Warwick HRI, Warwick, United Kingdom; (3) SUNY, Biological Sciences, Buffalo, United States |
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| Tobacco mosaic virus (TMV): a self-assembling nanotechnology template * A. Mueller (1), A. Kadri (1), G. Barralia (2), A.M. Bittner (2), H. Jeske (1), C. Wege (1) (1) Univ. Stuttgart, Stuttgart, Germany; (2) MPI, FKF, Stuttgart, Germany |
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| Promotorelements of Acanthocystis turfacea chlorella virus 1 (ATCV-1), a new Phycodnavirus, are active in prokaryotic cells Moritz Degen (1), * Artur J. P. Pfitzner (1) (1) Universität Hohenheim, Allgemeine Virologie, Stuttgart, Germany |
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| 11.00 – 13.00 h / Room Shanghai Workshop 3 Retroviruses I |
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| Chair: | Olivier Schwartz, Luc Willems | |
| Keynote Lecture: | Hans-Georg Kräusslich: | |
| 11.00 - 11.30 h | Assembly and entry of HIV | |
| 11.30 - 13.00 h | Oral presentations: | |
| High variety of STLV-1 strains in herbivore red colobus monkeys (Piliocolobus badius) * Sandra Junglen (1), Claudia Hedemann (1), Heinz Ellerbrok (1), Georg Pauli (1), Christophe Boesch (2), Fabian Leendertz (2) (1) Robert Koch-Institut, ZBS1, Berlin, Germany; (2) Max Planck Institut, Primatology, Leipzig, Germany |
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| HERV-K expression in melanomas * Silvia Hahn (1), Selma Ugurel (2), Kay-Martin Hanschmann (3), Heike Strobel (1), Christiane Tondera (1), Dirk Schadendorf (2), Johannes Löwer (1), Roswitha Löwer (1) (1) Paul-Ehrlich Institut, PR2/Retroelemente, Langen, Germany; (2) German Cancer Research Center Heidelberg and Department of Dermatology, University Hospital of Mannheim, Skin Cancer Unit, Mannheim, Germany; (3) Paul-Ehrlich Institut, Biostatistics, Langen, Germany |
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| Impact of Human and Porcine APOBEC3 Proteins on Replication of Porcine Endogenous Retrovirus * Eva Dörrschuck (1), Klaus Cichutek (1), Carsten Münk (1), Ralf Tönjes (1) (1) Paul-Ehrlich-Institut, Medical Biotechnology, Langen, Germany |
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| Towards a multi-transgenic rat model of HIV infection Christine Goffinet (1), Nico Michel (1), Ina Allespach (1), Daniel Rupp (1), Kerstin Ganter (1), Hanna-Mari Tervo (1), * Oliver Keppler (1) (1) University of Heidelberg, Virology, Heidelberg, Germany |
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| A TRIM Gene from Rabbit with broad Anti-Retroviral Activity * Torsten Schaller (1), Greg J. Towers (1) (1) University College London, Infection, London, United Kingdom |
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| Vpu-mediated downmodulation of CD4 is dispensable for efficient HIV-1 replication and CD4+ T cell depletion in ex vivo human lymphoid tissue * Michael Schindler (1), Devi Rajan (1), Anke Specht (1), Frank Kirchhoff (1) (1) University of Ulm, Institute of Virology, Ulm, Germany |
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13.00 - 14.00 h |
BREAK |
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| 14.00 – 16.00 h / Room Tokio Workshop 4 Receptors and Entry |
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| Chair: | Urs Greber, Göran Wadell | |
| Keynote Lecture: | Lukas Pelkmans: | |
| 14.00 - 14.30 h | Towards a taxonomy of viruses based on host requirement complexity | |
| 14.30 - 16.00 h | Oral presentations: | |
| Crystal structure of a SV40 VP1 pentamer in complex with its ganglioside receptor * Ursula Neu (1), Thilo Stehle (1) (1) University of Tübingen, Interfacultary Insitute for Biochemistry, Tübingen, Germany |
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| Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses * Sheli R. Radoshitzky (1), Jonathan Abraham (2), Christina F. Spiropoulou (3), Jens H. Kuhn (1), Dan Nguyen (2), Jane Nagel (1), Paul J. Schmidt (2), Jack H. Nunberg (4), Nancy C. Andrews (2), Michael Farzan (1), Hyeryun Choe (2) (1) New England Primate Research Center, Harvard Medical School, Southborough, MA, USA; (2) Children's Hospital, Harvard Medical School, Boston, MA, USA; (3) Centers for Disease Control and Prevention, Atlanta, GA, USA; (4) The University of Montana, Montana Biotechnology Center, Missoula, MT, USA |
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| Adenovirus type 11 binding alters the conformation of its receptor CD46 * David Persson (1), Dirk Reiter (1), Marko Marttila (2), Ya-Fang Mei (2), Jose Casasnovas (3), Niklas Arnberg (2), Thilo Stehle (1) (1) Institute for Biochemistry, Tübingen, Germany; (2) Department of Clinical Microbiology, Department of Virology, Umeå, Sweden; (3) Centro Nacional de Biotecnología, CSIC, Madrid, Spain |
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| Measles Virus (MV) attenuation: role of recognition of the ubiquitous membrane cofactor protein (MCP; CD46) * Claudia S. Antunes Ferreira (1), Marie Frenzke (1), G. Grant Welstead (2), Christopher D. Richardson (2), Roberto Cattaneo (1) (1) Mayo Clinic, Molecular Medicine Program, Rochester MN, USA; (2) University of Toronto, Department of Medical Biophysics and Ontario Cancer Institute, Toronto, Canada |
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| High-throughput siRNA screens to determine host factors involved in human adenovirus infections * Nina Wolfrum (1), Raphael Sacher (2), Berend Snijder (2), Lucas Pelkmans (2), Urs F. Greber (1) (1) University of Zurich, Zurich, Switzerland; (2) Swiss Federal Institute of Technology, Zurich, Switzerland |
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| Dual-color Herpes Simplex Viruses for the analysis of assembly, egress and cell entry * CH Nagel (1), M Fathollahy (1), T Strive (1), K Döhner (1), E Borst (1), M Messerle (1), B Sodeik (1) (1) Hannover Medical School, Institute of Virology, Hannover, Germany |
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| 14.00 – 16.15 h / Room Istanbul Workshop 5 Respiratory Viruses |
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| Chair: | Laurent Kaiser, Olli Ruuskanen | |
| Keynote Lecture: | Annika Linde: | |
| 14.00 - 14.30 h | Spread of viral respiratory tract infections in child-care - consequences and preventive strategies | |
| 14.30 - 16.15 h | Oral presentations: | |
| Patterns of Virus Infection in the Respiratory Tract Suggest a Causal Link to Serious Illness in Hospitalized Patients * Peter Coyle Belfast Hospital Trust, Regional Virus Lab, Belfast, UK |
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| Vaccination against human metapneumovirus * Bernadette van den Hoogen (1), Sander Herfst (1), Miranda de Graaf (1), Nancy Ulbrandt (2), Albert Osterhaus (1), Rik de Swart (1), Ron Fouchier (1) (1) ErasmusMC, Virology, Rotterdam, The Netherlands; (2) MedImmune, Gaithersburg, USA |
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| Characterisation of a patient-derived mutant of SARS-CoV by a novel T7 promoter-driven infectious cDNA clone * Susanne Pfefferle (1), Klaus Grywna (1), Christian Drosten (1) (1) Bernhard Nocht Institute for Tropical Medicine, Clinical Virology, Hamburg, Germany |
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| Interaction of SARS-CoV attenuated mutants with the host Marta L. DeDiego (1), E. Alvarez (1), K. Subbarao (2), E. W. Lamirande (2), S. Perlman (3), * Luis Enjuanes (1) (1) CNB, CSIC, Madrid, Spain; (2) NIH, MD, USA; (3) University of Iowa, Iowa, USA |
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| A reverse-genetic analysis of reassortant H1N2 human influenza A viruses * Aline Anton (1), Alla Heider (1), Larisa Mochalova (2), Nikolai Bovin (2), Brunhilde Schweiger (1), Thorsten Wolff (1) (1) Robert Koch-Institute, Berlin, Germany; (2) Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia |
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| NS1 of the 1918 pandemic virus and many avian strains of influenza A bind to the SH3 domains of the Crk/CrkL adapter proteins to regulate host cell signalling Leena Heikkinen (1), Arunas Kazlauskas (1), Ralf Wagner (2), Krister Melén (3), Thedi Ziegler (3), Ilkka Julkunen (3), * Kalle Saksela (1) (1) Department of Virology, Haartman Institute, University of Helsinki, Finland; (2) Institute of Medical Microbiology and Hygiene, University of Regensburg, Germany; (3) National Public Health Institute, Helsinki, Finland |
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| Recombinant modified vaccina virus Ankara (MVA)-based vaccine induces protective immunity in mice against infection with influenza virus H5N1 J.H. Kreijtz (1), * Y. Süzer (2), G. van Amerongen (1), G. de Mutsert (1), B. Schnierle (2), J.M. Wood (3), T. Kuiken (1), R.A. Fouchier (1), J. Löwer (2), A.D. Osterhaus (1), G. Sutter (2), G.F. Rimmelzwaan (1) (1) Erasmus MC, Rotterdam, The Netherlands; (2) PEI, Langen, Germany; (3) NIBSC, Potters Bar, United Kingdom |
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| 14.00 – 16.00 h / Room Shanghai Workshop 6 Hepatitis Viruses I (HBV) |
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| Chair: | Wolfram H. Gerlich, Michael Kann | |
| Keynote Lecture: | Fabien Zoulim: | |
| 14.00 - 14.30 h | Mechanisms of hepatitis B virus persistence and resistance to antivirals | |
| 14.30 - 16.00 h | Oral presentations: | |
| A structural model for duck hepatitis B virus core protein derived by extensive mutagenesis and antibody epitope mapping Jolanta Vorreiter (1), Immanuel Leifer (1), Christine Roesler (1), * Michael Nassal (1) (1) University Hospital Freiburg, Internal Med. 2 / Molecular Biology, Freiburg, Germany |
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| Hepatitis B viruses require cholesterol for endosomal escape during virus entry * Anneke Funk (1), Mouna Mhamdi (1), Carsten Lambert (2), Reinhild Prange (2), Heinz Hohenberg (1), Hüseyin Sirma (1) (1) Heinrich Pette Institut, Hamburg, Germany; (2) Institute for Medical Microbiology and Hygiene, Johannes-Gutenberg-University, Mainz, Germany |
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| Host factors involved in hepatitis B virus maturation * M. Rost (1), C. Lambert (1), T. Döring (1), R. Prange (1) (1) University of Mainz, Institute for Medical Microbiology, Mainz, Germany |
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| A triple function for the N-terminal domain of large hepatitis B virus surface protein: viral binding, antigenicity and influence on folding of the S-domain Corinna M. Leistner (1), Irina Sominskaya (2), Dace Skrastina (2), Paul Pumpens (2), Aiste Bulavaite (3), Kestas Sasnauskas (3), Wolfram H. Gerlich (1), * Dieter Glebe (1) (1) University of Giessen, Medical Virology, Giessen, Germany; (2) Biomed. Research and Study Centre, Riga, Latvia; (3) Institute of Biotechnology, Vilnius, Lithuania |
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| Suppression of HBV replication by Toll-like receptor activated non-parenchymal liver cells Jun Wu (1), Mengji Lu (2), Michael Roggendorf (2), * Jörg F. Schlaak (1) (1) University Hospital of Essen, Dept. of Gastroenterology and Hepatology, Essen, Germany; (2) University Hospital of Essen, Institute of Virology, Essen, Germany |
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| HBV specific adoptive immune transfer by living liver donation * A Schumann (1), M Lindemann (2), C Valentin-Gamazo (3), D Knop (4), U Dahmen (3), CE Broelsch (3), H Grosse-Wilde (2), M Roggendorf (1), M Fiedler (1) (1) University, Virology, Essen, Germany; (2) University, Immunology, Essen, Germany; (3) University, Surgery and Transplantation, Essen, Germany; (4) University, Transfusion medicine, Essen, Germany |
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16.00 - 16.30 h |
COFFEE BREAK |
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| 16.30 – 18.30 h Poster Session I (with wine and cheese) |
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