Program
| 09.00 – 10.30 h / Room Tokio Symposium II New Vaccination Strategies |
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| Chair: | Giorgio Palù, Klaus Überla | |
| Peter Palese: | Can we make better influenza virus vaccines? | |
| Ronald C. Desrosiers: | Overcoming HIV's strategies of immune evasion: the challenges of a vaccine for AIDS | |
| 10.00 - 10.30 h | Loeffler-Frosch Medal: | |
| Introduction: | Nikolaus Müller-Lantzsch | |
| Award Lecture: | Harald zur Hausen: Virus vaccination against cancer |
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10.30 - 11.00 h |
COFFEE BREAK |
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| 11.00 – 13.00 h / Room Tokio Workshop 13 Intrinsic and Innate Immunity |
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| Chair: | Manfred P. Dierich, Jay A. Levy | |
| Keynote Lecture: | Klaus Strebel: | |
| 11.00 - 11.30 h | Disarming innate antiretroviral defense mechanisms | |
| 11.30 - 13.00 h | Oral presentations: | |
| Foamy virus protein Bet induces delocalization and inhibits complex formation of APOBEC3 * Mario Perkovic (2), Henning Hofmann (2), Stanislaw Schmidt (2), Ferdinand Kopietz (2), Martin Löchelt (1), Klaus Cichutek (2), Carsten Münk (2) (1) DKFZ, Genome Modifications and Carcinogenesis, Heidelberg, Germany; (2) Paul-Ehrlich-Institut, Medical Biotechnology, Langen, Germany |
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| Increased APOBEC3-Expression in long-term non progressors (LTNPs) of SIV-Infected Macaques * Bianka Mussil (1), Dirk Motzkus (1), Ulrike Sauermann (1), Christiane Stahl-Hennig (1), Sieghart Sopper (1) (1) German Primate Center, Virology and Immunology, Goettingen, Germany |
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| PML and Daxx independently contribute to an intrinsic immune response against HCMV infection * Nina Tavalai (1), Thomas Stamminger (1) (1) Virologisches Institut, Universität Erlangen-Nürnberg, Germany |
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| The Cytomegalovirus pM27 Protein Disrupts Interferon JAK-STAT-Signaling by Recruiting STAT2 to the DNA Damage Binding (DDB1)-CUL4A E3 Ligase Complex Mirko Trilling (1), Albert Zimmermann (1), Manuela Fiedler (1), * Hartmut Hengel (1) (1) Universitätsklinikum Düsseldorf, Institut für Virologie, Düsseldorf, Germany |
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| Agonist of Proteinase-Activated Receptor-2 (PAR2) Enhances Anti-viral Effects of IFNγ on Human Monocytes * Victoria Shpacovitch (1), Micha Feld (1), Stefan Ludwig (2), Martin Steinhoff (1) (1) University of Münster, Dept of Dermatology, Münster, Germany; (2) University of Münster, ZMBE, Institute of Molecular Virology, Münster, Germany |
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| Summary Lecture: | Jay A. Levy: Overview: Innate Immunity in HIV Infection | |
| 11.00 – 13.00 h / Room Istanbul Workshop 14 Gene Therapy |
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| Chair: | David Klatzmann, Stefan Kochanek | |
| Keynote Lecture: | Mary Collins: | |
| 11.00 - 11.30 h | Engineering HIV for gene delivery | |
| 11.30 - 13.00 h | Oral presentations: | |
| Re-directed T cells eliminate HBV-infected hepatocytes Felix Bohne (1), Markus Chmielewski (2), Gregor Ebert (1), Stephan Urban (3), Hinrich Abken (2), * Ulrike Protzer (1) (1) University, Molecular Infectiology, Institute for Medical Microbiology, Cologne, Germany; (2) University Hospital, Tumor Genetics, Cologne, Germany; (3) University, Molecular Virology, Heidelberg, Germany |
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| The neutralizing antibody C2F5 as a secretable fusion inhibitor for gene therapy of HIV infection * Janine Kimpel (1), Sebastian Newrzela (1), Shweta Pahujani (1), Dorothee von Laer (1) (1) Georg-Speyer Haus, Frankfurt, Germany |
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| Chromosomal integration of adenovirus vector DNA in vitro and in vivo Sam Laurel Stephen (1), * Stefan Kochanek (2) (1) University of Cologne, ZMMK, Cologne, Germany; (2) University of Ulm, Division of Gene Therapy, Ulm, Germany |
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| CD133+ cells as targets for glioma gene therapy using adenovirus vectors Johan Skog (1), Karin Edlund (1), Tommy Bergenheim (2), * Göran Wadell (1) (1) Clinical Microbiology, Virology, Umeå, Sweden; (2) Radiation Sciences, Oncology, Umeå, Sweden |
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| Evaluation of 20 human adenovirus types and one infectivity-enhanced adenovirus for the therapy of softtissue sarcoma Dennis Hoffmann (1), Albert Heim (2), Dirk M. Nettelbeck (3), Steinstraesser Lars (4), *Oliver Wildner (1) (1) Ruhr University Bochum, Dep. for Virology, Bochum, Germany; (2) Hannover Medical School, Institut of Virology, Hannover, Germany; (3) University Heidelberg, German Cancer Research Center, Heidelberg, Germany; (4) Ruhr-University Bochum |
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| Development of an SIVsmmPBj- and a HIV-2-derived three-plasmid vector system * Björn-Philipp Kloke (1), Silke Schüle (1), Katrin Högner (1), Nina Wolfrum (1), Klaus Cichutek (1), Matthias Schweizer (1) (1) Paul-Ehrlich-Institut, Medical Biotechnology, Langen, Germany |
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| 11.00 – 13.00 h / Room Shanghai Workshop 15 Retroviruses II |
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| Chair: | Ben Berkhout, Kalle Saksela | |
| Keynote Lecture: | Jeremy Luban: | |
| 11.00 - 11.30 h | Host factors that restrict retroviral replication | |
| 11.30 - 13.00 h | Oral presentations: | |
| Characterization of the Vif Interaction domain in APOBEC3C * Björn-Philipp Kloke (1), Klaus Cichutek (1), Carsten Münk (1) (1) Paul-Ehrlich-Institut, Medical Biotechnology, Langen, Germany |
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| APOBEC3 proteins are major players in intracellular defense against human LINE-1 retrotransposition Heide Muckenfuss (1), Matthias Hamdorf (1), Axel Horn (2), Mario Perkovic (1), Johannes Löwer (2), Klaus Cichutek (1), Egbert Flory (1), Carsten Münk (1), * Gerald Schumann (2) (1) Paul-Ehrlich-Institut, Division of Medical Biotechnology, Langen, Germany; (2) Paul-Ehrlich-Institut, Section PR2/Retroelements, Langen, Germany |
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| RNA Requirments for the Incorporation of Pol Protein into Foamy Virus Particles * Tatiana Wiktorowicz (1), Katrin Peters (1), Axel Rethwilm (1) (1) Universität Würzburg, Institut für Virologie und Immunbiologie, Würzburg, Germany |
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| The role of viral and cellular factors that control translation of Human Immunodeficiency Virus Type-1 (HIV-1) RNA * Harriet Groom (1), Emma Anderson (1), John Dangerfield (2), Andrew Lever (1) (1) University Cambridge, Medicine, Cambridge, UK; (2) University of Veterinary Medicine, Research Institute of Virology and Biomedicine, Vienna, Austria |
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| DNA repair factors in foamy virus integration Tatjana Cornu (1), Benjamin Krause (1), * Christine Schuberth (1), Toni Cathomen (1) (1) Charité – Universitätsmedizin Berlin, Virologie (CBF), Berlin, Germany |
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| Modulation of Immunological Synapse Organization and Function by HIV-1 Nef Claudia Haller (1), Susanne Rauch (1), * Oliver Fackler (1) (1) Universitätsklinikum Heidelberg, Abteilung Virologie, Heidelberg, Germany |
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13.00 - 14.00 h |
BREAK |
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| 14.00 – 16.00 h Poster Session III |
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16.00 - 16.30 h |
COFFEE BREAK |
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| 16.30 – 18.30 h / Room Tokio Workshop 16 Adaptive Immunity and Immunoprevention |
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| Chair: | Barbara Ensoli, Stipan Jonjič | |
| Keynote Lecture: | Cornelis J. M. Melief | |
| 16.30 - 17.00 h | Immunoprevention and immunotherapy of high risk HPV-induced diseases | |
| 17.00 - 18.30 h | Oral presentations: | |
| Inconsistent responses of cytomegalovirus (CMV)-specific T-cells to pp65 and IE-1 vs infected dendritic cells in organ transplant recipients (OTR) Daniele Lilleri (1), Paola Zelini (1), Chiara Fornara (1), Giuditta Comolli (2), * Giuseppe Gerna (1) (1) Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; (2) Servizio di Virologia, Laboratori Sperimentali di Ricerca Area Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy |
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| A Randomized, Controlled, Phase II Study with an MVA-Nef Vaccine in HIV-1 Infected Patients Followed by Structured Treatment Interruption (STI) * T. Harrer (1), J. Hain (2), T. Meyer (2), N. Baedecker (2), V. Sobek (2), M. Baeuerle (1), H. Jaeger (3), M. Helm (4), D. Gorriahn (5), L. Schneider (6), E. Harrer (1) (1) University Hospital Erlangen, Dept. of Medicine III, Erlangen, Germany; (2) Bavarian Nordic GmbH, Martinsried, Germany; (3) Practice Jaeger, Munich, Germany; (4) Practice Helm, Nuremberg, Germany; (5) Practice Gorriahn, Munich, Germany; (6) Practice Schneider, Fürth, Germany |
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| Allogeneic CTL therapy for Epstein-Barr virus (EBV)-positive PTLD: Results of a phase II multicentre clinical trial * Tanzina Haque (1), Gwen Wilkie (2), Craig Higgins (3), Karen McAulay (2), Anthony Swerdlow (3), Dorothy Crawford (2) (1) Royal Free Hospital, Department of Virology, London, UK; (2) University of Edinburgh, CMV Laboratory, Edinburgh, UK; (3) ICR, Sutton, UK |
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| Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination * Wolfgang Kastenmüller (1), Georg Gasteiger (2), * Ingo Drexler (3) (1) TUM, Virology, Munich, Germany; (2) GSF, Virology, Munich, Germany; (3) GSF, Virology, Munich, Germany |
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| Seamless Modification of the HCMV Genome by GalK Mediated Recombineering: Generation of Recombinant Dense Bodies * Sabine Reyda (1), Véronique Mersseman (1), Bodo Plachter (1) (1) University of Mainz, Institute for Virology, Mainz, Germany |
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| Microsphere co-encapsulated PrP with CpG breaks self-tolerance to prion protein and induces CD4 and CD8 T cell responses Gunnar Kaiser-Schulz (2), Antje Heit (1), * Hermann Schätzl (2) (1) Technical University of Munich, Institute of Medical Microbiology, Munich, Germany; (2) Technical University of Munich, Institute of Virology, Munich, Germany |
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| 16.30 – 18.30 h / Room Istanbul Workshop 17 Negative Strand RNA Viruses II |
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| Chair: | Karl-Klaus Conzelmann, Veronika von Messling | |
| Keynote Lecture: | Paul Duprex: | |
| 16.30 - 17.00 h | Live cell imagining of paramyxovirus infection | |
| 17.00 - 18.30 h | Oral presentations: | |
| The fusion protein of respiratory syncytial virus (RSV) activates transcription factor p53 leading to apoptosis and shedding of epithelial cells * Julia Eckardt-Michel (1), Markus Lorek (1), Diane Baxmann (1), Gert Zimmer (1) (1) University of Veterinary Medicine, Institute of Virology, Hannover, Germany |
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| Measles virus P gene products inhibit Toll-like receptor 7/9 signaling * Christian Pfaller (1), Karl-Klaus Conzelmann (1) (1) Max von Pettenkofer-Institute & Gene Center, LMU, Munich, Germany |
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| Structural properties of phosphoproteins of Rhabdoviridae * Francine Gerard (1), Euripedes Ribeiro (1), Aurelie Albertini (1), Irina Gutsche (1), Rob Ruigrok (1), Marc Jamin (1) (1) UVHCI UMR5233 CNRS-UJF-EMBL, Grenoble, France |
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| Functional characterization of the major and minor phosphorylation sites of the P protein of Borna disease virus * Sonja Schmid (1), Daniel Mayer (1), Urs Schneider (1), Martin Schwemmle (1) (1) University of Freiburg, Department of Virology, Freiburg, Germany |
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| Influenza mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation? * Idoia Burgui Herrera (1), * Emilio Yángüez López-Cano (1), Nahum Sonenberg (2), Amelia Nieto Martín (1) (1) Centro Nacional de Biotecnología (C.S.I.C.), Departamento de Biología Molecular y Celular, Madrid, Spain; (2) McGill Cancer Center, McGill University, Department of Biochemistry, Montreal, Canada |
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| Inhibition of filovirus replication by the zinc finger antiviral protein Stefanie Müller (1), Peggy Möller (2), Matthew Bick (1), Stephanie Wurr (1), Stephan Becker (2), Stephan Günther (1), * Beate Kümmerer (1) (1) Bernhard-Nocht-Institute, Department of Virology, Hamburg, Germany; (2) Philipps University Marburg, Institute of Virology, Marburg, Germany |
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| 16.30 – 18.30 h / Room Shanghai Workshop 18 Positive Strand RNA Viruses |
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| Chair: | Tapani Hovi, John Ziebuhr | |
| Keynote Lecture: | John Ziebuhr: | |
| 16.30 - 17.00 h | The coronavirus replicase: special enzymes for special viruses | |
| 17.00 - 18.30 h | Oral presentations: | |
| Two non-infectious flaviviruses can form an infectious alliance * Christian Riepl (1), Christian Mandl (1) (1) Medical University of Vienna, Clinical Institute of Virology, Vienna, Austria |
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| Recombination of polioviruses- advantage to a recombinant strain? * Carita Savolainen-Kopra (1), Merja Roivainen (1), Anna-Kaisa Hiekka (1), Elena Samoilovich (2), Tapani Hovi (1) (1) Nat. Publ. Health Inst., Helsinki, Finland; (2) Res. Inst. of Epid. and Microb., Minsk, Byelorussia |
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| Characterization of IRES elements by a RNA virus based dual luciferase reporter system * Adriane Marschalek (1), Stefan Finke (2), Karl-Klaus Conzelmann (1) (1) Max von Pettenkofer-Institute & Gene Center, LMU Munich, Germany; (2) Friedrich-Loeffler-Institute, Insel Riems, Germany |
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| The Non-structural Protein 4A of Dengue Virus Is an Integral Membrane Protein Inducing Intracellular Membrane Alterations * Sven Miller (1), Jacomine Krijnse-Locker (2), Sandra Bühler (1), Ralf Bartenschlager (1) (1) Molecular Virology, Heidelberg, Germany; (2) EMBL, Heidelberg, Germany |
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| Activation of dsRNA-dependent protein kinase and induction of apoptosis in SARS-coronavirus-infected cells * Verena Krähling (1), Judith Küsters (1), Elke Mühlberger (1) (1) Philipps-University, Institute of Virology, Marburg, Germany |
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| Cytopathogenicity of Classical Swine Fever Virus Correlates With Attenuation in the Natural Host * Andreas Gallei (1), Sandra Blome (2), Volker Moennig (2), Paul Becher (1) (1) Institut für Virologie, Justus-Liebig-Universität, Giessen, Germany; (2) Institut für Virologie, Stiftung Tierärztliche Hochschule, Hannover, Germany |
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